Subthalamic stimulation modulates self-estimation of patients with Parkinson's disease and induces risk-seeking behaviour
Identifieur interne : 001041 ( Main/Exploration ); précédent : 001040; suivant : 001042Subthalamic stimulation modulates self-estimation of patients with Parkinson's disease and induces risk-seeking behaviour
Auteurs : Esther Florin [Allemagne, Canada] ; Désirée Müller [Allemagne] ; Johannes Pfeifer [Allemagne] ; Michael T. Barbe [Allemagne] ; Gereon R. Fink [Allemagne] ; Lars Timmermann [Allemagne]Source :
- Brain [ 0006-8950 ] ; 2013.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme, Prise de décision.
English descriptors
- KwdEn :
Abstract
Patients with Parkinson's disease with deep brain stimulation in the subthalamic nucleus postoperatively often display higher impulsivity and therefore may experience difficulties in social interactions. Here, we examined social interactions of patients with Parkinson's disease with and without deep brain stimulation in the subthalamic nucleus in competitive situations. We hypothesized altered self-estimation and risk-seeking behaviour in this patient group induced by deep brain stimulation in the subthalamic nucleus. To test the hypothesis, an experimental setting was used in which participants performed a calculation task and chose their preferred compensation. Based on their actual calculation performance, more patients with Parkinson's disease with deep brain stimulation chose a competitive tournament compensation. Assuming rational behaviour, this self-selection pattern reflects increased risk tolerance. Since patients who performed in the lowest quartile chose the tournament option, the data suggest that deep brain stimulation in the subthalamic nucleus results in a loss of the correct reference frame against which patients with Parkinson's disease evaluate their performance. The stimulation-induced combination of overestimation of their own performance, increased risk-taking, and preference for competitive environments despite poor performance is likely to impact considerably on the patients' social and work life.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000062
- to stream PascalFrancis, to step Curation: 000B71
- to stream PascalFrancis, to step Checkpoint: 000047
- to stream Main, to step Merge: 001054
- to stream Main, to step Curation: 001041
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Subthalamic stimulation modulates self-estimation of patients with Parkinson's disease and induces risk-seeking behaviour</title><author><name sortKey="Florin, Esther" sort="Florin, Esther" uniqKey="Florin E" first="Esther" last="Florin">Esther Florin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Cologne</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University Hospital Cologne</wicri:noRegion><wicri:noRegion>Department of Neurology, University Hospital Cologne</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University</s1><s3>CAN</s3><sZ>1 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName><orgName type="university">Université McGill</orgName></affiliation></author><author><name sortKey="Muller, Desiree" sort="Muller, Desiree" uniqKey="Muller D" first="Désirée" last="Müller">Désirée Müller</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Cologne</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University Hospital Cologne</wicri:noRegion><wicri:noRegion>Department of Neurology, University Hospital Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Pfeifer, Johannes" sort="Pfeifer, Johannes" uniqKey="Pfeifer J" first="Johannes" last="Pfeifer">Johannes Pfeifer</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Economics, University of Mannheim</s1><s3>DEU</s3><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Mannheim</wicri:noRegion><wicri:noRegion>Department of Economics, University of Mannheim</wicri:noRegion></affiliation></author><author><name sortKey="Barbe, Michael T" sort="Barbe, Michael T" uniqKey="Barbe M" first="Michael T." last="Barbe">Michael T. Barbe</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Cologne</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University Hospital Cologne</wicri:noRegion><wicri:noRegion>Department of Neurology, University Hospital Cologne</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute of Neuroscience and Medicine (INM-3), Cognitive Neuroscience, Research Centre Jülich</s1><s3>DEU</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Research Centre Jülich</wicri:noRegion><wicri:noRegion>Institute of Neuroscience and Medicine (INM-3), Cognitive Neuroscience, Research Centre Jülich</wicri:noRegion></affiliation></author><author><name sortKey="Fink, Gereon R" sort="Fink, Gereon R" uniqKey="Fink G" first="Gereon R." last="Fink">Gereon R. Fink</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Cologne</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University Hospital Cologne</wicri:noRegion><wicri:noRegion>Department of Neurology, University Hospital Cologne</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute of Neuroscience and Medicine (INM-3), Cognitive Neuroscience, Research Centre Jülich</s1><s3>DEU</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Research Centre Jülich</wicri:noRegion><wicri:noRegion>Institute of Neuroscience and Medicine (INM-3), Cognitive Neuroscience, Research Centre Jülich</wicri:noRegion></affiliation></author><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Cologne</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University Hospital Cologne</wicri:noRegion><wicri:noRegion>Department of Neurology, University Hospital Cologne</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">13-0365048</idno><date when="2013">2013</date><idno type="stanalyst">PASCAL 13-0365048 INIST</idno><idno type="RBID">Pascal:13-0365048</idno><idno type="wicri:Area/PascalFrancis/Corpus">000062</idno><idno type="wicri:Area/PascalFrancis/Curation">000B71</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000047</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000047</idno><idno type="wicri:doubleKey">0006-8950:2013:Florin E:subthalamic:stimulation:modulates</idno><idno type="wicri:Area/Main/Merge">001054</idno><idno type="wicri:Area/Main/Curation">001041</idno><idno type="wicri:Area/Main/Exploration">001041</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Subthalamic stimulation modulates self-estimation of patients with Parkinson's disease and induces risk-seeking behaviour</title><author><name sortKey="Florin, Esther" sort="Florin, Esther" uniqKey="Florin E" first="Esther" last="Florin">Esther Florin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Cologne</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University Hospital Cologne</wicri:noRegion><wicri:noRegion>Department of Neurology, University Hospital Cologne</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University</s1><s3>CAN</s3><sZ>1 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName><orgName type="university">Université McGill</orgName></affiliation></author><author><name sortKey="Muller, Desiree" sort="Muller, Desiree" uniqKey="Muller D" first="Désirée" last="Müller">Désirée Müller</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Cologne</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University Hospital Cologne</wicri:noRegion><wicri:noRegion>Department of Neurology, University Hospital Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Pfeifer, Johannes" sort="Pfeifer, Johannes" uniqKey="Pfeifer J" first="Johannes" last="Pfeifer">Johannes Pfeifer</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Economics, University of Mannheim</s1><s3>DEU</s3><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Mannheim</wicri:noRegion><wicri:noRegion>Department of Economics, University of Mannheim</wicri:noRegion></affiliation></author><author><name sortKey="Barbe, Michael T" sort="Barbe, Michael T" uniqKey="Barbe M" first="Michael T." last="Barbe">Michael T. Barbe</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Cologne</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University Hospital Cologne</wicri:noRegion><wicri:noRegion>Department of Neurology, University Hospital Cologne</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute of Neuroscience and Medicine (INM-3), Cognitive Neuroscience, Research Centre Jülich</s1><s3>DEU</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Research Centre Jülich</wicri:noRegion><wicri:noRegion>Institute of Neuroscience and Medicine (INM-3), Cognitive Neuroscience, Research Centre Jülich</wicri:noRegion></affiliation></author><author><name sortKey="Fink, Gereon R" sort="Fink, Gereon R" uniqKey="Fink G" first="Gereon R." last="Fink">Gereon R. Fink</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Cologne</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University Hospital Cologne</wicri:noRegion><wicri:noRegion>Department of Neurology, University Hospital Cologne</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute of Neuroscience and Medicine (INM-3), Cognitive Neuroscience, Research Centre Jülich</s1><s3>DEU</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Research Centre Jülich</wicri:noRegion><wicri:noRegion>Institute of Neuroscience and Medicine (INM-3), Cognitive Neuroscience, Research Centre Jülich</wicri:noRegion></affiliation></author><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Cologne</s1><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University Hospital Cologne</wicri:noRegion><wicri:noRegion>Department of Neurology, University Hospital Cologne</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Brain</title><title level="j" type="abbreviated">Brain</title><idno type="ISSN">0006-8950</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Brain</title><title level="j" type="abbreviated">Brain</title><idno type="ISSN">0006-8950</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Basal ganglion</term><term>Decision making</term><term>Estimation</term><term>Human</term><term>Interaction</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Risk factor</term><term>Self stimulation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Autostimulation</term><term>Estimation</term><term>Homme</term><term>Facteur risque</term><term>Noyau gris central</term><term>Prise de décision</term><term>Interaction</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term><term>Prise de décision</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with Parkinson's disease with deep brain stimulation in the subthalamic nucleus postoperatively often display higher impulsivity and therefore may experience difficulties in social interactions. Here, we examined social interactions of patients with Parkinson's disease with and without deep brain stimulation in the subthalamic nucleus in competitive situations. We hypothesized altered self-estimation and risk-seeking behaviour in this patient group induced by deep brain stimulation in the subthalamic nucleus. To test the hypothesis, an experimental setting was used in which participants performed a calculation task and chose their preferred compensation. Based on their actual calculation performance, more patients with Parkinson's disease with deep brain stimulation chose a competitive tournament compensation. Assuming rational behaviour, this self-selection pattern reflects increased risk tolerance. Since patients who performed in the lowest quartile chose the tournament option, the data suggest that deep brain stimulation in the subthalamic nucleus results in a loss of the correct reference frame against which patients with Parkinson's disease evaluate their performance. The stimulation-induced combination of overestimation of their own performance, increased risk-taking, and preference for competitive environments despite poor performance is likely to impact considerably on the patients' social and work life.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><country name="Allemagne"><noRegion><name sortKey="Florin, Esther" sort="Florin, Esther" uniqKey="Florin E" first="Esther" last="Florin">Esther Florin</name></noRegion><name sortKey="Barbe, Michael T" sort="Barbe, Michael T" uniqKey="Barbe M" first="Michael T." last="Barbe">Michael T. Barbe</name><name sortKey="Barbe, Michael T" sort="Barbe, Michael T" uniqKey="Barbe M" first="Michael T." last="Barbe">Michael T. Barbe</name><name sortKey="Fink, Gereon R" sort="Fink, Gereon R" uniqKey="Fink G" first="Gereon R." last="Fink">Gereon R. Fink</name><name sortKey="Fink, Gereon R" sort="Fink, Gereon R" uniqKey="Fink G" first="Gereon R." last="Fink">Gereon R. Fink</name><name sortKey="Muller, Desiree" sort="Muller, Desiree" uniqKey="Muller D" first="Désirée" last="Müller">Désirée Müller</name><name sortKey="Pfeifer, Johannes" sort="Pfeifer, Johannes" uniqKey="Pfeifer J" first="Johannes" last="Pfeifer">Johannes Pfeifer</name><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name></country><country name="Canada"><region name="Québec"><name sortKey="Florin, Esther" sort="Florin, Esther" uniqKey="Florin E" first="Esther" last="Florin">Esther Florin</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001041 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001041 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:13-0365048
|texte= Subthalamic stimulation modulates self-estimation of patients with Parkinson's disease and induces risk-seeking behaviour
}}
| This area was generated with Dilib version V0.6.29. |  |